Tumour suppressor function of protein tyrosine phosphatase receptor-T
نویسندگان
چکیده
منابع مشابه
Tumour suppressor function of protein tyrosine phosphatase receptor-T.
It has long been thought that PTPs (protein tyrosine phosphatases) normally function as tumour suppressors. Recent high-throughput mutational analysis identified loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes. PTPRT (protein tyrosine phosphatase receptor-T), a member of the family of type II...
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It is now well established that the members of the PTP (protein tyrosine phosphatase) superfamily play critical roles in fundamental biological processes. Although there has been much progress in defining the function of PTPs, the task of identifying substrates for these enzymes still presents a challenge. Many PTPs have yet to have their physiological substrates identified. The focus of this r...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2011
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20100134